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In humans, 5-LOX is expressed mainly in cells of myeloid origin (neutrophils, eosinophils, monocytes-macrophages, mast cells and dendritic cells) and in foam cells of atherosclerotic tissue (in other cells, synthesis is blocked by DNA methylation)

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Frias JP et al

Side effects such as nausea, diarrhea, or vomiting can lead to dehydration, further worsening dryness

And while these trials are promising and show similar short to medium-term safety, the oral form lacks the decade-plus of injectable data