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Extensive experimental and computational studies have shown that the binding of GSH to GSTs decreases the p K a of the GSH thiol group from around 9 to about 6 in the active site through hydrogen bonding and salt bridges and through the positive electrostatic potential of the G-site 41,42
Such integrative approaches could pave the way for more comprehensive obesity management strategies
S.XiuJ.DuanY.LiC.et al (2012)
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