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By 2017 revenue from liraglutide was US $843 million, and the overall market for GLP-1 drugs was growing 30 percent, up from just 3 percent in 2014 (Staton)

Issue: September 2025 FORMULATION DEVELOPMENT - Innovative Drug Delivery Approaches for GLP-1 Agonists: Enhancing Medication Adherence & Treatment Outcomes INTRODUCTION Obesity is a major global health issue, affecting more than 890 million adults

5,6 Thus, new T2D pharmacotherapy guidelines have recommended the use of GLP-1RAs for prevention and treatment of obese patients with risks of atherosclerotic cardiovascular diseases, whereas SGLT-2is has been proposed for patients with a risk of chronic heart failure

The lyophilization process removes moisture content to minimize microbial contamination risk during storage and handling

They trigger GH release through a different cascade (phospholipase C, inositol triphosphate, calcium mobilization) while partially suppressing somatostatin

Feb 2021;23(2):455-466