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(2012) 7:e39307

Results: Injection of FOXO4-DRI in both naturally aged and induced aging mice effectively suppressed aortic aging and improved aortic function

The significant increases of 24 h mean heart rate were seen in both groups

Zhu M, Zhu M, Wu X, Xu M, Fan K, Wang J, Zhang L, Yin M, Wu J, Zhu Z, Yang G

The trade-off is practical: MK-677 is oral, requires no injection skill, costs less, and produces faster visible changes that make compliance easier in human trials