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Hence, combining microglial targeting with supportive interventions on neuronal or astrocytic function may ultimately be necessary to achieve lasting neuroprotection

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For example, curcumin has been evaluated in Phase II clinical studies in pancreatic cancer and colorectal cancer patients, where oral doses up to 8 g/day demonstrated acceptable safety but limited systemic exposure, highlighting pharmacokinetic challenges

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doi: 10.1016/j.gendis.2018.05.001 2 WangD-YJiangZBen-DavidYWoodgettJRZacksenhausE