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Balanced Feedback While most Brello reviews are glowing, some users mention that GLP-1 medications can take time to adjust to and may cause mild side effects (like nausea) early on

GLP-1s vs Traditional Weight Loss Medications Older options like phentermine, orlistat, or naltrexone-bupropion typically produce 5-10% weight loss compared to 15-22% with GLP-1 medications

That does not mean instant rebound. It means tesamorelin is not usually framed in the literature as a one-and-done intervention

Protein intake becomes especially important during rapid weight loss

** Based on the treatment policy estimand: treatment effect regardless of if patients stayed on treatment or took other weight loss therapies

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