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Also, salvianolic acid B pretreatment induces Nrf2 and phase II enzymes by activating phosphoinositide 3-kinase (PI3K) and protein kinase C (PKC) pathways, thereby preventing acetaminophen-induced hepatotoxicity in mice (Lin et al., 2015)

Still, we should not disregard other AD models and their underlying theories

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It suggests either multiple pathways activated at different dose ranges or extreme potency with receptor saturation at low doses

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Curr Pharm Des 17: 16121632