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For example, if a patient experiences increased gastrointestinal side effects from a GLP-1 agonist while on hormonal therapy, adjustments may be necessary to optimise comfort and therapeutic outcomes

(126) observed that GLP-1R signaling exerted more robust control of -cell survival, relative to GIPR activation

Regardless, GLP-1s commonly result in constipation as a side effect, so say researchers in The American Journal of Gastroenterology

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