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In vivo data were analysed with a two-way ANOVA followed by Tukeys post-hoc test (fasted glucose levels, ipGTT glucose excursion, body weight and food intake) or a one-way ANOVA followed by Dunnetts or Tukeys post-hoc test (glucose AUC, terminal fat and clinical chemistry data)
These types of positive outcomes dont appear to be atypical
In this Article, the EC 50 values at human GCGR and GLP-1R for cyclic adenosine monophosphate (cAMP) second messenger signalling were set as the optimization targets