FDA staff had recommended against including emideltide, which is used for insomnia and opioid withdrawal, on the list in part because studies on its efficacy are limited and because there are alternative therapies available to treat those conditions
The main challenge with oral glutathione supplements is their poor bioavailability
Second, many available studies are characterized by small sample sizes or lack appropriate control groups, making it difficult to draw definitive conclusions about therapeutic efficacy and optimal treatment protocols
Without sufficient glutathione, melanin regulation gets disrupted, leading to hyperpigmentation or uneven spots
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