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Research indicates selective cellular pathway modulation in controlled experimental conditions

Finally, they reflect pathways likely additional to those involved in the angiogenesis (Vukojevic et al., 2018), recently associated in particular with the increased expression, internalization of VEGFR2, and the activation of the VEGFR2-Akt-eNOS signaling pathway (Hsieh et al., 2017) (see Genes Expression as Support ), given the rapid presentation of all of these effects, which occurred before the process of angiogenesis could be initiated (Sikiric et al., 1993

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Published dosing context mainly involves topical clinical-study use, diabetic-ulcer wound studies, and newer registered topical wound-healing trials, not an FDA-approved injectable label [3], 7