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[11] Because these vitamins are not long-term cumulative drugs (they dont maintain stable plasma levels like a blood pressure medication would), missing one dose is usually not critical

At 300 mcg, which is the standard current protocol, the effect size is likely more modest still

Once reconstituted in bacteriostatic water, the solution is typically held at 28C and used within the documented stability window

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Yes, they are generally safe when administered by trained professionals in accordance with clinical guidelines