Originally formulated to treat type 2 diabetes, GLP-1s have also been shown to help with cardiovascular disease, serious liver disease, and in the case of Zepbound, sleep apnea
Renal function should be monitored, especially if patients experience significant gastrointestinal symptoms that could lead to dehydration
For tirzepatide versus semaglutide, contrary to the primary endpoint in the head-to-head comparison, there was some supporting evidence for tirzepatide to have a modest benefit, although the 95% CI overlapped the null (HR 0.91, 95% CI 0.81 to 1.01) (Fig
The US CDC suggests about 150 minutes of moderate activity each week
The 0.9% concentration is calibrated to provide effective bacteriostasis at the anticipated microbial challenge levels associated with multi-use vial access in laboratory research environments while remaining below the concentration ranges associated with peptide and protein stability perturbation in reconstituted research compound solutions
Expectations from phase 2 were pointing towards 14-15% weight loss vs 11.2%, but this is why we perform clinical trials