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Tolerability (preclinical): Each peptide is generally well tolerated in animal studies, with occasional mild injection-site reactions

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Since these medications can produce harmful side effects, patients should take medications only under the supervision of a provider with expertise in the treatment of dysautonomias

This correlation of cytokine levels with severity may indicate that severity is a useful way to subgroup ME/CFS, as well as a dose-response defect in the metabolism or excretion of cytokines (231)

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