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The c-Fos activation patterns in the AP, NTS, PB, and CeA are well described for other appetite-modulating compounds, including glucagon (84), lithium chloride (8587), amylin (87), and GLP-1 (18)

Endocrinology (2003) 144(11):492330

Adding a medication that further reduces BMD compounds an existing vulnerability

Nobody is going to fund massive clinical trials on compounds that dont align with the pharmaceutical profit machines end goals

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Indeed, GLP-1RAs have evolved over time such that the frequency of dosing has decreased from twice-daily (exenatide, BD) [65], to once-daily (liraglutide, lixisenatide) [66, 67] to once-weekly (dulaglutide, exenatide QW, semaglutide) [5, 6], suggesting a higher adherence potential for the longer-acting agents (Table 2)