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A distance of 1-2 inches from the wound edge is typically recommended
Cardiovascular safety data from published trials showed reductions in systolic blood pressure (ranging from 4.3 to 7.9 mmHg depending on dose) and diastolic blood pressure (2.3 to 4.6 mmHg reductions)
Cold powder dissolves slower and may not fully reconstitute
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It's commonly used as a diluent for preparing injectable medications
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