Due to the uncertainty regarding the optimum balance of GLP-1R and GCGR agonism in a unimolecular co-agonist, development of novel peptides varied from sequence modification and enhancing stability of native OXM, sequence modification of the glucagon peptide to confer increased GLP-1R potency or modification of GLP-1 peptide to confer increased GCGR potency
In the full episode, I cover: -The state of evidence for alleged geroprotective effects of GLP-1 receptor agonists, SGLT2 inhibitors, methylene blue, and telomere-lengthening supplements -Risks and benefits associated with low-dose aspirin for cardiovascular disease (CVD) prevention -Evidence regarding optimal protein intake for maximizing muscle mass, and whether follistatin gene therapy might have promise for further increasing muscle gains -How to apply evidence-based reasoning to separate science from speculation in longevity research -More This AMA episode (Ep
The fix: weigh weekly under consistent conditions (morning, after bathroom, before food)
Low Starting Dose A common research starting point is a low daily amount
So, what should you do when taking a GLP-1
Reduced glutathione helps combat oxidative stress and inflammation, two key factors in aging