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Taking an oral capsule with food may be easier on the stomach, but food could also change absorption

This phenomenon speeds up aging and the development of age-related diseases

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Similarly, although hepatic dysfunction can occur with large niacin doses (1-3 grams daily over months) causing elevated liver enzymes or jaundice, niacinamide at 100 mg is very unlikely to have any adverse effect on the liver

psychological symptoms such as depression or psychosis