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Weight 420-500g

361 (94%) participants had evaluable biomarker data for the current analyses

Another important aspect is that, because compounding oversight is typically less stringent than for commercial drug manufacturers, the risk of substandard products is significantly higher

For testing the difference in mean and median lifespan between groups, we used linear mixed model with linear quantile mixed-effects model, which included cage assignment as a random effect and batch as a covariate, respectively, using package nlme and lgmm in statistical software R

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