AGEs may cause vascular dysfunction by making cross-bonds between extracellular matrix proteins (elastin and collagen), which leads to blood vessel stiffness, heart fibrosis, and diastolic dysfunction 12
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Before & After: Setting Realistic Tirzepatide Expectations The ideal candidate for tirzepatide therapy is typically someone with a BMI of 30 or higher, or a BMI of 27 or higher accompanied by weight-related comorbidities such as hypertension, high cholesterol, insulin resistance, or type 2 diabetes
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By targeting GLP-1, GIP, and glucagon receptors, researchers are exploring whether multi-pathway therapy can produce deeper metabolic effects than earlier medications
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