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70 Additionally, lactylation at K91 of transcription factor EB (TFEB) impedes it from interacting with E3 ubiquitin ligase WW domain-containing E3 ubiquitin protein ligase 2 (WWP2), thereby inhibiting TFEB ubiquitination and proteasome degradation and eventually augmenting TFEB activity

2021;16(6):e0252899

10.1016/j.redox.2021.101947 Redox Biol

Answer: Good candidates are adults struggling with persistent hunger, a stalled response to GLP-1 medications, insulin resistance, or a long history of weight cycling, who want to address the hormonal driver of appetite rather than rely on restriction alone

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Scientific References Off-label or unlicensed use of medicines: prescribers' responsibilities