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Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions
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In HEK293 cells expressing human GIP receptor or GLP-1 receptor, tirzepatide potently stimulated cAMP accumulation by both receptors, and the potency of tirzepatide was similar to that of native GIP and approximately 13-fold weaker than that of GLP-1 in these assays [88]
Long-term deficiency can cause tingling, numbness, and in severe cases, irreversible nerve damage
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