tirzepatide gip & glp-1 Designing a dual GLP-1R/GIPR agonist from | DDDT Tirzepatide | GLP-1R and GIPR

Exploring a New Strategy When weight seems to yo-yo despite consistent effort, and obesity-related health conditions like type 2 diabetes, high blood pressure, or sleep apnea become harder to manage, it may be time to consider a more lasting approach

Jalleh RJ, Jones KL, Rayner CK, Marathe CS, Wu T, Horowitz M

These gastrointestinal issues, including vomiting and abdominal distention, were among the most frequently reported in Phase I trials

Because obtaining FDA approval is so hard, Congress has incentivized costly investment in breakthrough medicines by granting statutory exclusivities (distinct from intellectual property rights) that allow innovators to be, for a time, the only lawful source of that medicine

In this metabolic pathway, the cofactor carnitine is crucial since it serves as a shuttle-molecule to allow fatty acid acyl moieties entering the mitochondrial matrix where these molecules are oxidized via the -oxidation pathway

Think of the GLP-1 system like a company-wide email network