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Rybelsus (semaglutide)
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Table 46 Composition of co-formulation vehicles varying in HP-B-CD content and molar substitution degree as well as in overall buffer composition 1 MS: molar substitution, corresponds to hydroxy propyls per glucose unit Preparation process Formulations were prepared as described in example 1 except that active pharmaceutical ingredients were not added
Standard / Gradual Approach (3 mL = ~6,667 mcg/mL) Reconstitute: Add 3.0 mL bacteriostatic water to one 20 mg blend vial ~6,667 mcg/mL total blend (a 10 mg vial ~3,333 mcg/mL)
doi:10.1111/dom.14255
Khandia, R
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