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It also showed beneficial impacts on glycemic and blood pressure control as well as lipid metabolism in hypertensive patients without serious adverse effects such as liver and kidney dysfunction [181]
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Among GSTLs, the active site motif is found around position 40 and it is mostly of the CP[F/Y]A form
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By contrast, under nutrient-depleted or amino acid starvation conditions, intracellular glutathione levels progressively decline, thereby lowering the execution threshold for GPX4 inhibition-induced ferroptosis
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