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Retinoid discontinuation creates the benchmark comparison since topical vitamin A derivatives (tretinoin, adapalene, retinol) represent gold-standard anti-aging treatment with decades of research and user experience documenting post-treatment outcomes

Peptides are short chains of amino acids that act as signaling molecules in the body

Peptides offer a theoretically different approach: addressing tissue biology rather than just inflammation

This suggests that the overactive immune response eventually becomes exhausted or overcome by counter-regulatory mechanisms

Any use outside of a supervised clinical trial setting would be inappropriate and potentially unsafe