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Consistently, the GPx3 levels were reported to be down-regulated in aggressive inflammatory breast cancer (IBC) carcinoma tissues compared to non-IBC tissues, and this down-regulation was associated with hypermethylation of the GPx3 promoter [103]

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Zhong L, Zhang S, Tang K, Zhou F, Zheng C, Zhang K, et al

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Thus, unlike WT-Bcr-Abl cells, T315I-Bcr-Abl cells are less vulnerable to JMF4073 in vitro and in vivo