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Atherosclerosis-model mice treated with exendin-4, another GLP-1RA, also demonstrated reduced circulating levels of monocyte chemoattractant protein-1, C-X-C motif chemokine ligand-1 (CXCL-1), and ultimately neutrophil recruitment (Wang et al., 2014)

First isolated in 1977 from rabbit cerebral venous blood, DSIP is classified as amphiphilic, meaning it contains both water-attracting and water-repelling regions

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Overall, the paper suggests that the effect of GLP-1-based drugs on muscle appears to be comparable to that of natural weight loss except for the different molecular signature, which may have yet undiscovered long-term effects

The SURMOUNT-4 trial with tirzepatide showed that participants who continued the medication lost an additional 5.5% of their body weight, while those who switched to a placebo regained 14%

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