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Zhou Q, Lei X, Fu S, et al

CBS deficiency led to markedly homocysteine accumulation and severely decreased levels of cystathionine and cysteine, which was due to impaired homocysteine removal through the transsulfuration pathway [32]

The SELECT trial extended that finding to non-diabetic overweight and obese populations with a 20% MACE reduction (HR 0.80, 95% CI 0.72 to 0.90) across 17,604 participants

Researchers have documented the safety profile observed in published Phase 2 research as predominantly gastrointestinal effects (nausea, diarrhoea, vomiting) typical of the incretin class, occurring most prominently during dose escalation and tending to decline with continued exposure (PMID 39515565, PMID 41785010)

First, it promotes the growth of blood vessels by stimulating the secretion of VEGF