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The effect of GLP-1R-based agonists on the hepatic and extra-hepatic complications of MASLD Hepatic diseases The MR analyses indicated that the genetically proxied effects of GLP-1R/GIPR agonists were causally associated with reduced risk of liver cancer (OR: 6.07 10 6 , 95%CI: 8.65 10 8 4.26 10 4 , P = 3.04 10 8 ) while all of the GLP-1R-based agonists did not provide evidence for MASH, chronic hepatitis, liver fibrosis, liver cirrhosis, and hepatic failure (Table 4)