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In our analyses of GLP-1-receptor agonists, which included 92 exposed events, the HR vs use of sulfonylureas was 1.25 (95% CI 0.89, 1.76)
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10.3389/fmicb.2019.01423 31 CuthbertsonJ.PattersonS.OHarteF
This glucose-dependence is the reason why GLP-1 agonists rarely cause hypoglycaemia in monotherapy unlike sulfonylureas which stimulate insulin secretion regardless of glucose level Glucagon suppression: Semaglutide suppresses glucagon secretion from pancreatic alpha cells also in a glucose-dependent manner
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