glp 1 neurodegenerative disease GLP-1 mimetics and cognition The promise of GLP-1 receptor

To date, GLP-1R has been identified presynaptically on GABAergic nerve terminals (Rebosio et al., 2018) and on medium spiny neurons that express the dopamine-D1 or dopamine-D2 receptors (Zhang et al., 2020)

This marks the first time a biosimilar of liraglutide has been introduced in India, following approval from the Drug Controller General of India (DCGI)

(6) B Greenwood-Van Meerveld, K Tyler, E Mohammadi, and C Pietra (2012) Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus Journal of Experimental Pharmacology, 2012 Oct 19, Volume 4, Pages 149-55

The journey with GLP-1s is a marathon, not a sprint

A doctor typically orders it for a specific reason: suspected malabsorption, long-term nutrition delivered through a vein, dialysis, an unexplained cardiomyopathy, or a suspicion that someone has been taking far too much of a supplement

First, an IPGTT was done on all three genotypes to examine the glucose excursion profile 30 minutes after SC EX-4 administration (10 nmol/kg) ( Figure 3A )