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Importantly, proteolytic cleavage of SPARC (secreted protein acidic and rich in cysteine), a matricellular protein abundantly expressed at sites of vascular injury and tissue remodeling, generates GHK-containing fragments that promote endothelial cell proliferation and neovascularization

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Furthermore, zonulin was already increased in two independent cohorts in a subset of patients with RA-specific autoimmunity that had not yet developed the disease (pre-RA) (Fig