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The Nesprin-2 SRs are required for actin patch formation To dissect the roles of the LINC complex in nuclear tension and actin patch formation, we used a mouse mini-Nesprin-2 protein (CB) that lacks SRs 3-54, but can still bind to the actin cytoskeleton through its CH domain (Fig
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ROS can damage your DNA, a process known as oxidative stress
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