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These may include: Muscle cramps or weakness Increased heart rate Seizures in individuals with seizure disorders Worsening of hypothyroid symptoms Gastrointestinal discomfort in sensitive individuals If any of these symptoms occur, its important to discontinue use and seek medical advice immediately

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Reference: Nicotinamide N-Methyltransferase in Cardiovascular Diseases: Metabolic Regulator and Emerging Therapeutic Target (2025)