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Increased homocysteine, aside from the MTHFR genetic variation, may make people more susceptible to other conditions like cardiovascular disease, increased risk of coronary artery disease (CAD) and blood clots in the arteries and veins

Some individuals carry genetic variants that reduce carnitine carrier expression, making supplementation more impactful for their metabolic rate and fat oxidation capacity

The primary difference is half-life

However, human studies specifically measuring cortisol levels in people taking semaglutide remain limited, making this an area of ongoing investigation

Additionally, the medication had a good safety profile , with only mild to moderate gastrointestinal side effects and no liver safety issues