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But strategic combinations can cover the inflammatory, barrier, and antimicrobial aspects of the disease

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For instance, in a randomised, placebo-controlled, double-blind Phase I study of ascending single doses of cotadutide in healthy individuals with overweight, there were dose-dependent improvements in glucose excursions post meal within 24 h and food intake reduction after a single dose of 100 g [82]

Nat Comm (2021) 12:5417

Corey Williams and unpacks how these drugs can induce starvation states that ripple far beyond weight-loss, with potential consequences for mental health, mood, and vulnerability

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