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Yet, GLP-1 is mainly localized to the distal small bowel and colon and is released following nutrient intake [12, 13] and it has been shown that M1 and M2 muscarinic receptors may also be involved in the regulation of GLP-1 release [14]

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Dulaglutide significantly reduced the risk of this primary composite outcome by 12% compared to placebo (p=0.026)