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If the weight management indication is denied, your clinician may explore the cardiovascular indication (Wegovy) or the sleep apnea indication (Zepbound) if clinically appropriate

Kim YC, Guan KL

The subjects were randomly assigned to receive subcutaneous semaglutide at doses of 0.5 mg or comparator medications (placebo, sitagliptin, exenatide extended-release, or insulin glargine)

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Albiglutide was less effective in activating the GLP-1R compared to exendin-4 in an in vitro study of a BHK cell line expressing the rat GLP-1R (92)