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It plays a critical role in detoxifying the body, neutralizing toxins, and maintaining cellular integrity

Su S, Ding Y, Li Y, et al

Furthermore, because some NAPQI is created regardless of the function of the other 2 pathways, failure in the glutathione-dependent pathway is expected to result in the accumulation of NAPQI and subsequent toxicity, even if the other 2 pathways are functional.It is not surprising that both sulfation- and glutathione-dependent pathways are aberrant in the same population because they are metabolically connected [41,72,73]

64 NBDHEX and its analogs NBDHEX (6-[7-nitro-2,1,3-benzoxadiazol-4-ylthio]hexanol) is a recently developed compound designed as a mechanism-based inhibitor that exerts potent effects on GST

Phillips, D

Bradshaw, P