In a 52-week randomized, double-blind, placebo-controlled phase 2 trial involving 64 adults at high fracture risk (due to low BMD or recent fragility fractures), participants received once-weekly semaglutide (1.0 mg) or placebo
Loss of H3K27 trimethylation was more frequent in Triton subtype (21 of 22
At the current cost GLP-1 agonist users would expect to pay anywhere between $150 to $600 AUD/ month depending on the choice of medication and their respective dosing
Moving to the ability of metformin to reduce the metastatic potential, it was demonstrated that the drug not only reduced the migration of MTC cancer cells (Klubo-Gwiezdzinska et al., 2012), but also modified the expression of several markers of the epithelial-tomesenchimal-transition (EMT) (Han et al., 2015)
No flashing lights
Mechanistically, JTC801 disrupts lysosomal pH, leading to cholesterol accumulation and activation of SREBF2, a master transcriptional regulator of sterol biosynthesis