Its a mechanical aidlike drinking a glass of water before eating, but with a slightly longer gastric emptying time due to the protein matrix
You have ongoing constipation, reflux, or nausea thats reducing your food and fluids
However, if the A1c is 60 mg/mmol, or progressive increase in UACR despite appropriate therapy, eGFR 30% increase in serum creatinine within 3 months of starting SGLT2i, ACEi, or ARB, inability to achieve target BP, or signs/symptoms of another underlying kidney disease, such as glomerulonephritis
Spots were counted by Immuno-SpotS6 Ultra Analyzer (Cellular Technology, Inc., Santa Monica, CA)
Arch Gerontol Geriatr 46: 181190.
The second is dose and route translation : even where an effect is real in a mouse, the human-equivalent dose is not a simple body-weight scaling, and as the route section above stressed there is no human bioavailability figure to anchor an oral-versus-injected comparison