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Obesity or being overweight are major risk factors for cardiovascular disease and events like heart attacks, and semaglutide has been shown to help reduce the risk of these occurrences

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So a drug company wouldnt be too keen on a trial like that unless they were sure their drug was either better or at least as good as

Once frozen, the medication becomes useless, even if it looks fine after thawing

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GLP-1 medications, without exercise, often cause muscle loss, slowing metabolism over time