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doi:10.1007/s00125-012-2776-x Muscelli E, Mari A, Casolaro A et al (2008) Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients
On the first question, the clinical evidence base for GLP-1 receptor agonists is substantial and well-documented across multiple independent research organizations
Saxenda 3 mg daily for weight management): Proven efficacy with 5-8% weight reduction and cardiovascular outcome benefits in the LEADER trial Dulaglutide (Trulicity 0.75-4.5 mg weekly): Convenient once-weekly dosing with demonstrated cardiovascular benefit in the REWIND trial Tirzepatide (Mounjaro for diabetes
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the value comes from reading them as a set
If it only worked for diabetics, these trials would have failed spectacularly
