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It is a two ATP-requiring enzymatically catalyzed process.[] After its synthesis, glutathione gets distributed in intracellular organelles, including endoplasmic reticulum (ER), nucleus, and mitochondria.[] NUCLEAR GLUTATHIONE In the nucleus, GSH prevents the oxidation of sulfhydryl groups of several proteins to disulfide groups

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The treatment plan, including dosage and frequency, should be tailored to individual health needs and goals, commonly ranging from weekly to monthly injections

These findings highlight the dose-dependent toxicity of NAC and emphasize the need for cautious dosing, particularly in healthy individuals (159)