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As evidence accrues, we, and others, will monitor what it means for the impact of GLP-1 medications on SMM, but so far we have not seen any compelling clinical data (although new systematic reviews and meta analyses have been proposed ) that GLP-1 medications lead to pathological skeletal muscle mass loss relative to what has been demonstrated and observed in other weight loss interventions

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Focus on a comprehensive approach

I don't want to gain the weight back. Hes lost about 90 pounds since he started taking GLP-1s in March 2022 and is no longer prediabetic

Patients using oral contraceptives should be aware that tirzepatide may reduce the effectiveness of these medications, particularly during initiation and dose escalation

You think youre large for your whole life and you look [back] and youre like, 'I was fit.' Yeah, I had big muscles