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Unlike other diabetes medications such as Ozempic and Wegovy, which primarily target the GLP-1 pathway to suppress appetite, or Mounjaro, which contains GLP-1 plus GIP to control blood-sugar levels, retatrutide also engages the glucagon receptor, which helps increase energy expenditure

Choose retatrutide if: Retatrutide may be the better option for other specific profiles

GI symptom rates nearly doubled when participants skipped titration steps

[24] What GLP-1 Is and Why Your Gut Is the Source GLP-1 is an incretin hormone: a gut-derived signal that helps coordinate what happens after you eat