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DOI: 10.1159/000065402

We propose that the effects of cumulative loss of surface receptor with fast-internalizing, slow-recycling, lysosome-targeting agonists, along with increases in -arrestin-induced desensitization, become more apparent with time, eventually overriding any positive effects associated with noncanonical signaling

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Animal studies use doses and conditions that do not always translate directly to human outcomes

HGH therapy increases lean body weight but decreases abdominal and visceral fat