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But, as scientists and food formulators learn more about how these drugs affect both diet and consumption patterns, its becoming clear that such consumers should not be treated as a single, monolithic segment

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Treatment duration varies

Even small percentage volume shifts translate into billions

the problem is when smaller meals become protein-light and nutrient-light

An estimand accounts for these intercurrent events [Citation27], ensuring alignment of the objectives with the design, conduct, and analysis of a trial