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Declining NAD+ impairs energy, metabolism, skin health, and immunity, accelerating biological aging.[12][13] Research indicates that this loop can be interrupted by boosting NAD+, potentially reversing aspects of biological age as measured by epigenetic clocks

This review study highlights the biological effects of different NAD+ boosters as well as the unique benefits of direct NAD+ administration over oral precursors because it bypasses gut and liver metabolism

Other important safety information Do not use B12/MIC if you are currently pregnant, breastfeeding, or plan to become pregnant or breastfeed

There is significant evidence that fetal neural tube defects can be prevented if folic acid therapy is initiated before pregnancy and continued during pregnancy

Certain medications The following drugs can reduce levels of vitamin B12 in your body: Antibiotics -- long-term use can lower vitamin B levels generally Anti-seizure drugs Chemotherapy medicines, especially methotrexate Drugs used to reduce stomach acid, like H2 blockers (Pepcid AC, Tagamet, Zantac) and proton pump inhibitors (Nexium, Prevacid, Prilosec) Metformin (Glucophage) -- taken for diabetes Colchicine -- taken for gout Some cholesterol-lowering medications Other causes You're over 65